Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The knowledge of solubility and solution thermodynamics for 2-amino-4,6-dichoropyrimidine in different solvents is essential for its purification and further theoretical studies. In this work, the solid-liquid equilibrium for 2-amino-4,6-dichoropyrimidine in ten neat solvents (methanol, ethanol, n-propanol, isopropanol, acetone, acetonitrile, ethyl acetate, 1,4-dioxane, toluene and cyclohexane) and binary liquid mixtures (ethyl acetate + ethanol) was established with the isothermal saturation method at temperatures T = (278.15 to 318.15) K under pressure of 101.2 kPa, and the solubility of 2-amino-4,6-dichoropyrimidine in these solvents were determined by a high-performance liquid chromatography (HPLC). In general, the equilibrium solubility was highest in 1,4-dioxane and lowest in cyclohexane. The achieved solubility values in monosolvents were correlated by the modified