Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Three antofloxacin salts (antofloxacin hydrochloride, anoxifloxacin sulfate and anoxifloxacin succinate) solubility in six organic solvents including methanol, ethanol, n-propanol, n-butanol, acetonitrile and N,N-dimethylformamide (DMF) were determined experimentally over a temperature range from (273.15 to 318.15) K under 101.3 kPa. Within the temperature range studied, the solubility of these three compounds in the solvents increased with a rise of temperature. The solubility values of antofloxacin hydrochloride in these six solvents obey the following order: (methanol, DMF) greater than n-butanol greater than ethanol greater than n-propanol greater than acetonitrile. For the systems of anoxifloxacin sulfate + solvents, it ranked as: DMF greater than methanol greater than ethanol greater than acetonitrile greater than n-propanol greater than n-butanol. While anoxifloxacin succinate + solvents, the order of the data from high to low is: DMF greater than methanol greater than n-butanol greater than n-propanol greater than ethanol greater than acetonitrile. The solubility data obtained of these three compounds in the studied solvents were correlated by using the modified Apelblat equation, h equation. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 3.3x10-5 and 4.06%, respectively. Generally, the RAD values