Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of trimetazidine hydrochloride in twelve neat solvents namely ethanol, methanol, isopropanol, n-propanol, acetone, toluene, 2-butanone, ethyl acetate, n-butanol, acetonitrile, N,N-dimethyl formamide (DMF) and 1,4-dioxane and binary liquid mixtures methanol + (ethanol, DMF or ethyl acetate) was measured using the isothermal method over the temperature range from 278.15 K to 323.15 K under local atmospheric pressure of 101.2 kPa. The observed mole fraction solubility was largest in methanol and smallest in toluene. The experimental data in monosolvents was correlated through Apelblat equation; while in mixed solvents, by the van't Hoff-Jouyban-Acree model, Jouyban-Acree model and Apelblat-Jouyban-Acree model. Consequently, for the selected monosolvents, the largest relative average and root-mean-square deviations were 0.79 % and 0.227x10-4, respectively; and for the binary solvent mixtures, 3.00 % and 2.22x10-4. Solvent-solvent and solute-solvent interactions were analyzed in the twelve net solvents with linear solvation energy relationship analysis. The solubility in monosolvents depends significantly upon the Hildebrand parameter and nonspecific dipolarity/polarizability interactions. The values of log x12 deviated from the mean values of log x12 in the monosolvents. Results were interpreted based on different modes of the solvation interactions.