Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this study, the solubility of 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide (APMC) in pure tetrahydrofuran, ethyl acetate, acetonitrile, n-butanol, n-propanol, ethanol, methanol and three binary solvent mixtures (ethyl acetate + methanol, ethyl acetate + ethanol, ethyl acetate + n-butanol) was firstly experimentally determined within the temperature range from (278.15 to 328.15) K under atmosphere pressure by gravimetric method. The results reveal that the solubility of APMC increases with the increasing temperature in all solvents selected. The modified Apelblat equation and the Buchowski-Ksiazaczak h equation were used to correlate the experimental solubility in pure solvents while the modified Apelblat equation, the CNIBS/R-K model and the Jouyban-Acree model were applied to correlate the solubility in binary solvent mixtures. All the models could be well applied and the modified Apelblat equation stood out to be more suitable with a higher accuracy than the other three models.