Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility data of 2-chlorophenylacetic acid in solid-liquid equilibrium were indispensable for a preliminary industrial application aimed at purifying and renewing. In this paper, the solubility of 2-chlorophenylacetic acid in twelve alternative solvents (toluene, water, acetonitrile, ethylacetate, ethylbenzene, n-propanol, isopropanol, n-butanol, isobutanol, cyclohexane, 2-butanone and acetone) at atmospheric pressure and temperatures ranging from 273.15/283.15 to 318.15K, were determined by the isothermal saturation method. Upon the analysis of the experimental data, the mole fraction solubility increased when the solution temperature increased. Generally, the solubility order in different solvents is as follows: 2-butanone greater than (acetone, isopropanol, ethyl acetate, n-propanol, isobutanol, n-butanol) greater than acetonitrile greater than toluene greater than ethylbenzene greater than cyclohexane greater than water. Thermodynamic models such as modified Apelblat equation, Eh equation, Wilson model and NRTL model were chosen to fit and correlate the obtained solubility data. Some association parameter could be obtained. The maximum value of root-mean-square deviation (RMSD) is 48.72 ~10-4, and the maximum relative mean deviation (RAD) is 1.86%. Besides, the mixing properties of the solutions were obtained, including the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration ( 1 A ) and reduced excess enthalpy ( E, 1 H ).The course of dissolution is spontaneous , through study of solubility and thermodynamic was helpful to the purification process of 2-chlorophenylaceticacid.