Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility of florfenicol form A in eight pure organic solvents (propionic acid, ethanol, 1-propanol, 1-butanol, 2-propanol, 2-methyl-1-propanol, 3-methyl-1-butanol, 2-ethyl-1-hexanol) and three binary solvents (dimethyl sulfoxide + ethanol, dimethyl sulfoxide + 1-propanol and dimethyl sulfoxide + 1-butanol) were measured by a laser dynamic method at the temperature from 283.15K to 323.15K. The experimental results show that the mole fraction solubility of Florfenicol in the pure solvents decreased according to the following order: ethanolgreater than 1-propanolgreater than2-propanolgreater than1-butanolgreater than3-methyl-1-butanolgreater than2-methyl-1-propanol propionic acidgreater than 2-ethyl-1-hexanol. The experimental results show that the mole fraction solubility of florfenicol form A in the binary solvents increased with the increase of temperature and dimethyl sulfoxide mass fraction. The experimental solubility data were well correlated with the four thermodynamic models: modified Apelblat equation, h equation, NRTL model equation, Wilson model equation. The modified Apelblat model equation was regarded as the best one to fit the experimental values in the pure solvents.