ABSTRACT

The aim is to study the solubility of aniracetam and discuss the molecular interaction in dissolution process. This work would be useful for optimizing the crystallization and extraction process of aniracetam. The equilibrium data of aniracetam in methanol, ethanol, n-propanol, isopropanol, acetone, toluene, ethyl acetate and three binary mixtures were determined by using isothermal saturation method with temperatures ranging from (273.15 to 318.15) K. The solubility of aniracetam in pure and mixed solvents increased with the increasing temperature. At given temperature, the solubility of aniracetam in (acetone + alcohols) increased with increasing mass fraction of acetone. Moreover, it was greater in (acetone + methanol)

Compounds

#	Formula	Name
1	C12H13NO3	1-(4-methoxybenzoyl)pyrrolidin-2-one
2	CH4O	methanol
3	C2H6O	ethanol
4	C3H8O	propan-2-ol
5	C3H6O	acetone
6	C3H8O	propan-1-ol
7	C7H8	toluene
8	C4H8O2	ethyl acetate

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 5	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 8	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 7	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 2	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 3	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 6	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 4	Mole fraction - 1 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	10
POMD	1 5 2	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 5; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	70
POMD	1 5 3	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 5; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	70
POMD	1 5 4	Mole fraction - 1 ; Liquid	Temperature, K; Liquid Solvent: Mass fraction - 5; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	Chromatography	70

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Aniracetam Solubility in Pure and Binary Solvents: Effect of Molecular Interaction and Analysis of Crystallized Products

Shao, Danfeng, Yang, Zehui, Zhou, Guoquan

ABSTRACT