Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Volumetric Properties of Local Anesthetical Drug Lidocaine Hydrochloride in Aqueous and in Aqueous NaCl Solutions at Different Temperatures

Shaikh, Vasim R., Salunke, Vidya R., Behare, Karishma P., Patil, Sayali E., Borse, Amulrao U., Patil, Kesharsingh J.
J. Chem. Eng. Data 2018, 63, 5, 1498-1506
ABSTRACT
We report in this communication, the data on density measurements of binary aqueous solutions of lidocaine hydrochloride LC*HCl (0.00978 to 0.25412 molkg-1) as well as for ternary aqueous solutions containing a fixed concentration (0.09787 molkg-1 and 1.00764 molkg-1) of sodium chloride (NaCl) and varying the concentration (0.02046 to 0.24929 molkg-1) of LC*HCl at 288.15, 293.15, 298.15, 303.15 and 308.15 K. The density data are used to determine apparent molar volume ( V ) of the drug LC*HCl molecule at finite concentrations as well as apparent molar volume at infinitely dilute solutions ( V0 ) in water and in aqueous NaCl solutions. The limiting apparent molar expansivity ( E0 ) parameter of LC*HCl in binary and ternary aqueous NaCl solutions at 293.15, 298.15 and 303.15 K have also been computed. The transfer volume trV0 , that is, volume change occurring when LC*HCl is transferred from water to aqueous NaCl solutions are calculated. All these results are analyzed and discussed on the basis of solute-solvent, lidocaine cation-cation and embrionic micelle forming interactions in aqueous salt solutions. Corresponding Author. E-mail: patilkesharsingh@hotmail.com
Compounds
# Formula Name
1 C14H23ClN2O lidocaine hydrochloride
2 ClNa sodium chloride
3 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 3
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 5
  • POMD
  • 1
  • 3
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 60
  • POMD
  • 1
  • 3
  • 2
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Molality, mol/kg - 2; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 105
  • POMD
  • 3
  • 2
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 10