Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubility data of sodium L-ascorbate in water, methanol, ethanol, acetone, chloroform, ethyl acetate, isopropanol, isobutanol, n-hexane, water-methanol mixture and water-ethanol mixture have been determined in the temperatures range of 278.15-323.15 K by a static analytic method at atmospheric pressure. The experimental data were correlated with the modified Apelblat equation, CNIBS/R-K model and Jouyban-Acree model. Based on the solubility data, a novel model-free design approach (semi-supersaturation control, SSSC) for combined cooling and anti-solvent crystallization (CCAC) processes has been proposed and evaluated for sodium L-ascorbate in methanol-water mixture. This approach can be easily implemented without complicated on-line monitors. Sodium L-ascorbate crystals with large and uniform morphology were obtained using CCAC process, which was designed by the SSSC approach.