Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solid-liquid equilibrium data of L-carnitine fumarate in methanol + (ethanol/ 1-propanol/ 2-propanol) binary mixed systems was determined at temperature ranging from 288.15 K to 328.15 K, while the solubility data of L-carnitine fumarate in (methanol + 1-butanol) mixtures was determined from T = (293.15 to 333.15) K due to its low solubility in low temperature. All experimental data was obtained by gravimetric method under atmospheric pressure. At each composition point, the data increases with the increasing temperature in all determined solutions, similar trend is also observed when mole fraction of methanol increases in all binary solvent mixtures for each temperature. It is also found that the solubility data of L-carnitine fumarate in these binary mixtures ranks as (methanol + ethanol) greater than (methanol + 1-propanol) greater than (methanol + 2-propanol) greater than (methanol + 1-butanol). The modified Apelblat equation, (CNIBS)/Redlich Kister model, Solubility-Polarity model and Jouyban-Acree model were employed to correlate the solubility data determined, and all of them show good agreement with experimental value. Furthermore, the crystal morphology and size distribution of L-carnitine fumarate in different solvents was studied in order to select favorable solvents for good crystal habits.