Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Vitamin E acetate (VEA) exhibits promising pharmacological action in pharmaceutical and cosmetic industry. The solubility of Vitamin E acetate (VEA) in supercritical carbon dioxide is measured to determine the cloud-point pressures in a high-pressure variable-volume view cell at various temperatures (i.e., 308.15 K, 313.15 K 318.15 K, 323.15 K, 328.15 K ) and pressure range ( 8~15 MPa ). The experimental results indicate that the solubility of VEA can be improved by increasing pressure and reducing temperature in the experimental range. Furthermore, four density-based semi-empirical models are employed to correlate and predict the experimental results, including Chrastil, Kumar and Johnston (K-J), Bartle and Mendez-Santiago and Teja (MST) equations. The theoretical calculation results are greatly consistent with the determinatal results. The relevant AARD values of Chrastil, K-J, Bartle and MST is 6.62%, 6.83%, 6.80% and 7.19%, respectively.