Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this work, the solid-liquid equilibrium for thiamphenicol in thirteen neat solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, acetone, acetonitrile, ethyl acetate, 2-butanone, toluene, water, N,N-dimethylformamide and 1,4-dioxane) was built with the static method at temperatures T = (278.15 to 318.15) K under pressure of 101.2 kPa, and the thiamphenicol solubilities in these solvents were determined by using high-performance liquid chromatography. Generally, the solubility data in mole fraction obeyed the following order from high to low in the selected solvents: N,N-dimethylformamide greater than acetone greater than methanol greater than 1,4-dioxane greater than 2-butanone greater than ethanol greater than acetonitrile greater than ethyl acetate greater than n-propanol greater than isopropanol greater than water greater than n-butanol greater than toluene. The NRTL model, modified Apelblat equation, Wilson model and Eh equation were employed to describe the solubility behavior of thiamphenicol in theses solvents. The maximum values of RMSD and RAD were 4.08 ~10-4 and 2.02 %, respectively, and the correlation results with modified Apelblat equation were best among the four models. Additionally, the mixing Gibbs energy, mixing enthalpy, mixing entropy, activity coefficient at infinitesimal concentration and reduced excess enthalpy were derived.