Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

A gravimetric method was used to determine the solubility of quetiapine fumarate (QF) in nine pure solvents and two aqueous binary solvents (water + methanol/ethanol) at different temperatures from 283.15 K to 323.15 K. The solubility of QF increases with the increase of temperature in nine pure solvents, and it is in the order DMF greater than methanol greater than ethanol greater than 1-butanol greater than isobutanol greater than isopropanol greater than acetone greater than ethyl acetate greater than water at a given temperature. Solubility of QF in the binary solvents also shows temperature dependence, while at a given temperature the solubility is mainly influenced by the solvent composition with the presence of maximum, reflecting cosolvency. Also the solubility of QF increases with the increase of temperature in binary solvents in a given composition. Hansen solubility parameters was used to explain the cosolvency and maxima shift, confirming that for large values (greater than25 MPa1/2) of solute, the solubility shows a peak in the range of 35 to 31 MPa1/2 of solubility parameters of alcohol mixtures. The experimental solubility of QF in pure and binary solvents is well correlated by modified Apelblat equation, the NRTL model and the CNIBS/R-K equation, respectively.