Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

For the effective drug design and development, an integrated process utilizing all available information from structural, thermodynamic and biological studies play a very important role. To understand the energetic basis of molecular interactions utilizing various thermodynamic methods, volumetric and acoustic studies is vital early in the development process of any drug towards an optimal energetic interaction profile while retaining good pharmacological assay. In the present paper, we are reporting the data of densities (n ) and speeds of sound ( u ) of an Antiarrhythmic agent namely procainamide hydrochloride in aqueous binary and aqueous solution of amino acids i. e. L-alanine and L-valine at T = (298.15, 308.15 and 318.15) K. Different thermodynamic parameters such as apparent molar volume (Vo ) of solute, isentropic compressibility ( ) s e of the solution, apparent molar isentropic compressibility (e ) o of procainamide hydrochloride in water and aqueous solutions of L-alanine and L-valine have been computed using the density and speed of sound data at different temperatures. The limiting apparent molar volume ( 0 Vo ) of solute, limiting apparent molar compressibility (eo0 )of solute in binary and ternary aqueous solution have been obtained by extrapolating the plots. The results have been interpreted in the light of the competing solute-solute and solute-solvent interactions.