Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

With the intention of explore the bile salts applications as drug delivery vehicles, the mixed interfacial as well as micellar behavior of sodium salt of ibuprofen (NaIbuF) and bile salts mixtures in aqueous/electrolyte solutions has been evaluated by tensiometric method. Bile salts (sodium cholate (NaC) and sodium deoxycholate (NaDC)) used in present study is anionic in nature and form small micelles. Various hypothetical models such as Clint, Rubingh as well as Rosen were utilized to acquire information concerning the nature of interaction among the components in the solution as well as at the interface. Due to the attendance of inorganic salt (100 mmol.kg-1 NaCl) decrease in the surface charge of the micelles takes place ensuing micellization occurs at poorer concentration. An attractive interaction was obtained in the micelle and at interface, because it is obvious from interaction parameters ( Om, O a). The values of poundsGG0 m for all systems attained to be negative in absence as well as occurrence of salt. Micelle aggregation number (Nagg), estimated by means of steady-state fluorescence quenching studies, suggest that the contribution of bile salts was always more than that of the NaIbuF. Micropolarity (I1/I3), Stern-Volmer binding constants (Ksv) as well as dielectric constant (Dexp) of mixtures has also supported the synergistic behavior of the drug-bile salts mixed systems.