Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Ionic Liquid Influenced Synergistic Interaction between Amitriptyline Hydrochloride and Cetyltrimethylammonium Bromide

Khan, Abbul Bashar, Wani, Farooq Ahmed, Dohare, Neeraj, Parray, Mehraj ud din, Singh, Prashant, Patel, Rajan
J. Chem. Eng. Data 2017, 62, 10, 3064-3070
ABSTRACT
The mixed micellization behavior of amitriptyline hydrochloride (AMT) with cetyltrimethylammonium bromide (CTAB) has been studied at different mole fractions in the presence of imidazolium based ionic liquid 1-butyl-3- methyl imidazolium hydrochloride (Bmim.Cl), by using electrical conductivity at different temperatures from 298 K to 318 K. A shift in the Tmax value (i.e., the temperature at which cmc value is maximized) has been observed with the rise in CTAB mole fraction. Synergistic interaction is explained by the deviations in critical micelle concentration (cmc) from ideal critical micelle concentration (cmc*) and micellar mole fraction (Xm) from ideal micellar mole fraction (Xideal) values. The calculated thermodynamic parameters (viz., the standard Gibbs energy change, o Gm , the standard enthalpy change, o m H , and the standard entropy change, o m S ), suggest the dehydration of hydrophobic part of the drug at higher temperatures in case of AMT as well as in CTAB-AMT binary systems in presence of Bmim.Cl whereas the temperature at which dehydration occur changes with rise in mole fraction of CTAB.
Compounds
# Formula Name
1 C8H15ClN2 1-butyl-3-methylimidazolium chloride
2 C20H24ClN 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidine)-N,N-dimethyl-1-propanamine hydrochloride
3 C19H42BrN N,N,N-trimethyl-1-hexadecanaminium bromide
4 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 4
  • 2
  • Electrical conductivity, S/m ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 2; Liquid
  • Solvent: Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Alternating current cell with electrodes
  • 152
  • POMD
  • 1
  • 4
  • 3
  • Electrical conductivity, S/m ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 3; Liquid
  • Solvent: Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Alternating current cell with electrodes
  • 160
  • POMD
  • 1
  • 4
  • Electrical conductivity, S/m ; Liquid
  • Temperature, K; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Alternating current cell with electrodes
  • 10