Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Esomeprazole sodium was a proton pump inhibitor (PPI) synthesized using omeprazole sulfide. In this paper, we used a static-analytic method to analyze the solubility of our own synthesis of esomeprazole sodium in ethyl acetate, acetonitrile, methyl isobutyl ketone, ethanol, methanol, and in the (ethanol + ethyl acetate) mixtures between 278.15 and 328.15 K. A group of thermodynamic models were selected such as the Jouyban Acree equation, the modified Apelblat equation, and CNIBS/R-K equations. All equations can be well applied and the modified Apelblat equations are relatively better. We determined the thermodynamic properties of esomeprazole sodium using the van t Hoff equation furthermore, including the entropy, Gibbs energy, and enthalpy.