Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

Development and design of crystallization process strongly depends on accurate solid-liquid equilibrium data. In this paper, the solubility data of amorphous cefmetazole sodium in pure solvents (ethanol, n-propanol, i-propanol, n-butanol,n-amyl alcohol, ethyl acetate, n-butyl acetate,n-hexane and cyclohexane) and binarysolvent mixtures (methanol and ethanol) weremeasured by usingUV spectroscopic method and gravimetrical method respectively at temperatures from (278.15 to 313.15) K.The results show that the solubility data of cefmetazole sodium increase with the increasing of temperature in all investigated solvents and decrease with the rising of the mole fraction of ethanol in the binary solvent mixtures.The Apelblat equation wassuccessfully used to correlate the experimental solubility data in pure solvents and the Apelblat equation, the CNIBS/R-K model and the Jouyban-Acree model were successfully applied to correlate the solubility data in methanol + ethanol systems. It was found that the correlated dataare in good agreement with the experimental data. Additionally, the molecular surface electrostatic potential (MSEP) correlated with the solubility data was alsocalculated and used to explain the difference of the solubility data of amorphous cefmetazole sodium in various solvents.