The sulfasalazine melting temperature and molar enthalpy have been determined by the DSC method. The shake flask method has been used to measure the drug solubility in buffer solutions (oI 2.0 and 7.4), hexane and octanol and to determine the distribution coefficients in the octanol/buffer systems in the temperature range of 293.15 - 313.15 K. The calculated thermodynamic functions were then used to study the influence of the solvent type and sulfasalazine protolytic properties on the drug dissolution and distribution.
Compounds
#
Formula
Name
1
C18H14N4O5S
Sulfasalazine
2
C8H18O
octan-1-ol
3
C6H14
hexane
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.