Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

In this paper, the solubility of Methyl D-(-)-4-hydroxy-phenylglycinate was measured under the different pH levels, pure solvents, mixed solvents, ionic strength and impurities in the temperature range from 283 to 323 about 5 K intervals by using laser method at atmospheric pressure. The results reveal that the solubility of Methyl D-(-)-4-hydroxy-phenylglycinate increases with increasing temperature in all selected solvents Cwhile decreases with increasing mole fraction composition of water in the mixed solvents. The solubility curve of Methyl D-(-)-4-hydroxy-phenylglycinate in the aqueous solution at different pH is gU h shape and the solubility of Methyl D-(-)-4-hydroxy-phenylglycinate increases with concentrations of ammonium chloride, and has no obvious changes when its concentration up to 1.2 mol/L. It is beneficial to maximize the reaction conversion rate of D-4-hydroxyphenylglycine Methyl ester hydrochloride and reduce the residual D-4-hydroxyphenylglycine Methyl ester hydrochloride on reactive crystallization of Methyl D-(-)-4-hydroxy-phenylglycinate. Furthermore, the modified Apelblat equation and CT=C0 ( H +/k1+k2/ H ++1) type correlation regression model have made good correlation of the experimental solubility in pure solvents, mixed solvents and the aqueous solution at different pH, respectively.