Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Solubility of Fenofibrate in Different Binary Solvents: Experimental Data and Results of Thermodynamic Modeling

Sun, H.[Hua], Liu, B.[Baoshu], Liu, P.[Peihua], Zhang, J.[Junli], Wang, Y.[Yongli]
J. Chem. Eng. Data 2016, 61, 9, 3177-3183
ABSTRACT
Solubility of fenofibrate in ethanol water and acetone water mixtures was investigated using dynamic laser monitoring at atmospheric pressure and temperatures between 278.15 and 308.15 K. Solubility increased as temperature and the fraction of organics increased. The solubility data was correlated with the modified Apelblat, NRTL, combined nearly ideal binary solvent/Redlich Kister (CNIBS/R K), and Jouyban Acree (J A) models. Solvent composition and temperature correlations were conducted, and the apparent dissolution enthalpy, entropy, and Gibbs free energy change of the fenofibrate were calculated using the modified Apelblat model and the van t Hoff equation. The results shoLw that the dissolution of fenofibrate is endothermic and nonspontaneous, and that the main contributor in the binary solvents studied is enthalpy.
Compounds
# Formula Name
1 C20H21ClO4 fenofibrate
2 C2H6O ethanol
3 C3H6O acetone
4 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 1
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 2
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Titration method
  • 35
  • POMD
  • 3
  • 4
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mole fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Titration method
  • 30
  • POMD
  • 2
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Titration method
  • 7
  • POMD
  • 3
  • 1
  • Mole fraction - 1 ; Liquid
  • Temperature, K; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • Titration method
  • 6