ABSTRACT

The solubility of berberine chloride in several imidazolium-based ionic liquids (ILs), that is, [Rmim]BF4, [Rmim]NO3, [Rmim]PF6, and [Rmim]NTf2 (R = butyl, hexyl, and octyl), were measured using a laser monitoring observation method from 299.45 to 364.35 K at atmospheric pressure. The solubility of berberine chloride in selected ionic liquids increased as the temperature increased and is dominantly dependent on the type of IL s anion structure with the trend of NTf2 >greater than NO3 greater than PF6 greater than BF4 . The ILs with NTf2 anion exhibited good dissolubility to berberine chloride, especially at high temperature. The correlated solubility data via Apelblat equation is in better agreement with the experiment solubility compared to Dual parameter equation and h equation.

Compounds

#	Formula	Name
1	C8H15N3O3	1-butyl-3-methylimidazolium nitrate
2	C10H19N3O3	1-hexyl-3-methylimidazolium nitrate
3	C12H23N3O3	1-methyl-3-octylimidazolium nitrate
4	C6H11BF4N2	1-ethyl-3-methylimidazolium tetrafluoroborate
5	C8H15BF4N2	1-butyl-3-methylimidazolium tetrafluoroborate
6	C10H19BF4N2	1-hexyl-3-methylimidazolium tetrafluoroborate
7	C12H23BF4N2	1-methyl-3-octylimidazolium tetrafluoroborate
8	C8H15F6N2P	1-butyl-3-methylimidazolium hexafluorophosphate
9	C10H19F6N2P	1-hexyl-3-methylimidazolium hexafluorophosphate
10	C12H23F6N2P	1-octyl-3-methylimidazolium hexafluorophosphate
11	C10H15F6N3O4S2	1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide
12	C12H19F6N3O4S2	1-hexyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide
13	C14H23F6N3O4S2	1-octyl-3-methylimidazolium bis[(trifluoromethyl)sulfonyl]imide
14	C20H18ClNO4	9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolinium chloride

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	14 4	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	6
POMD	14 5	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	7
POMD	14 6	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	8
POMD	14 7	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	9
POMD	14 1	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	11
POMD	14 2	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	9
POMD	14 3	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	10
POMD	14 8	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	5
POMD	14 9	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	5
POMD	14 10	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	6
POMD	14 11	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	10
POMD	14 12	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	9
POMD	14 13	Mole fraction - 14 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 14	Visual	8

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Determination and Correlation of the Solubility for Berberine Chloride in Pure Imidazolium-Based Ionic Liquids

Ge, L.[Li], Bao, A.[Anxian], Yang, K.[Kedi]

ABSTRACT