Dissolution thermodynamics of camptothecine in chloroform, methanol, ethanol, and {chloroform + (methanol or ethanol)} mixed organic solvents were studied and correlated. The solubility of camptothecine in the above solvents was measured over the temperature range of 275.76 328.42 K at around 3 K intervals at atmospheric pressure. Experimental results showed that the solubility of camptothecine in the mixtures solvents increased with the increasing temperature. The mole fraction solubility of camptothecine reached a maximum at the mole fraction of chloroform 0.8016 in chloroform + methanol mixed solvent and 0.8031 in chloroform + ethanol mixed solvent. The experimental solubility data were well-correlated by using the modified Apelblat equation, the h equation, and the ideal equation, respectively. The h equation was proved to be the best-fit model for correlating the solubility of camptothecine from the analysis of the Akaike s Information Criterion (AIC).
Compounds
#
Formula
Name
1
C20H16N2O4
camptothecine
2
CH4O
methanol
3
C8H8O2
4-methylbenzoic acid
4
C2H6O
ethanol
5
CHCl3
trichloromethane
6
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.