Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

The solubilities of (+)-biotin intermediate lactone in methanol, toluene, tetrahydrofuran, dichloromethane, ethyl acetate, N,N-dimethylformamide were determined at the investigated temperature (287.15 to 323.75) K under pressure (p = 0.1 MPa) by a laser monitoring system. The solubilities of (+)-biotin intermediate lactone in pure solvents increase with increasing temperature and in the following order: methanol less than toluene less than ethyl acetate less than tetrahydrofuran less than dichloromethane less than N,N-dimethylformamide. The solubilities were correlated by the equation for ideal solution model, modified Apelblat equation, eh equation, Wilson model and NRTL equation. The calculated values are in good agreement with the measured experimental data. The modified Apelblat equation was found to provide further accurate representation of the experimental data in six organic solvents.