ABSTRACT

Density (), speed of sound (u), and viscosity () measurements of amino acids l-glutamine and l-histidine in aqueous solutions of metformin hydrochloride (an antidiabetic drug) (0.01, 0.07, and 0.13 mol*kg 1) were carried out in the concentration range (0.02 0.20 mol*kg 1) at 293.15, 298.15, 303.15, 308.15, and 313.15 K. The experimental data has been meticulously used to enumerate various parameters which assist to procure valuable information regarding the presence of different kinds of intermolecular interactions present in the ternary (metformin hydrochloride + water + amino acids) system. The results were interpreted in terms of various metformin hydrochloride amino acid intermolecular interactions through a cosphere overlap model. The ion ion interactions are the key players in ternary system and these interactions are of higher order in the case of histidine as compared to glutamine. Also application of transition state theory has been made to calculate the thermodynamic activation parameters for metformin hydrochloride/amino acid mixture solutions. An increase in the entropy of the transition state has been observed which may be due to bond breaking. Furthermore, structure making behavior of both amino acids has been observed in metformin solution.

Compounds

#	Formula	Name
1	C5H10N2O3	L-glutamine
2	C6H9N3O2	L-histidine
3	C4H12ClN5	N,N-dimethylimidodicarbonimidic diamide hydrochloride
4	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 3 4	Mass density, kg/m3 ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	215
POMD	1 3 4	Speed of sound, m/s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	215
POMD	1 3 4	Viscosity, Pa*s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	215
POMD	2 3 4	Mass density, kg/m3 ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	200
POMD	2 3 4	Speed of sound, m/s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	200
POMD	2 3 4	Viscosity, Pa*s ; Liquid	Solvent: Molality, mol/kg - 3; Liquid Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	215
POMD	1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	50
POMD	1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	50
POMD	1 4	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	50
POMD	3 4	Mass density, kg/m3 ; Liquid	Molality, mol/kg - 3; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	3 4	Speed of sound, m/s ; Liquid	Molality, mol/kg - 3; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15
POMD	3 4	Viscosity, Pa*s ; Liquid	Molality, mol/kg - 3; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	15
POMD	2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	50
POMD	2 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	50
POMD	2 4	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Capillary tube (Ostwald; Ubbelohde) method	50

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Intermolecular Interactions of L-glutamine and L-histidine in Aqueous Solutions of Metformin hydrochloride: Volumetric, Compressibility and Viscometric Studies

Chauhan, S.[Suvarcha], Singh, K.[Kuldeep], Kumar, K.[Kuldeep], Neelakantan, S.[Sundaresan], Kumar, G.[Girish]

ABSTRACT