ABSTRACT

Experimental solubility of lamotrigine in binary mixtures of methanol + acetone, ethanol + acetone, 1-propanol + acetone, ethyl acetate + acetone, ethyl acetate + methanol, ethyl acetate + ethanol, ethyl acetate + 1-propanol at 298.2 K are reported. The measured data were fitted to the Jouyban Acree model and the overall mean percentage deviation (MPD) of back-calculated solubilities was 4.0 %. Also, densities of the saturated solutions were measured and fitted to the Jouyban Acree model. The overall MPD value for this analysis was 6.0 %.

Compounds

#	Formula	Name
1	C9H7Cl2N5	lamotrigine
2	C2H6O	ethanol
3	CH4O	methanol
4	C3H6O	acetone
5	C3H8O	propan-1-ol
6	C4H8O2	ethyl acetate

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	3 4 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 3; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	3 4 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 3; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	2 4 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 2; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	2 4 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 2; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	4 5 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 5; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	4 5 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 5; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	4 6 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 6; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	4 6 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 6; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	3 6 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 6; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	3 6 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 6; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	2 6 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 6; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	2 6 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 6; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	5 6 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Solvent: Mass fraction - 6; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid Crystal - 1	UV-spectroscopy	11
POMD	5 6 1	Mass density, kg/m3 ; Liquid	Solvent: Mass fraction - 6; Liquid Amount concentration (molarity), mol/dm3 - 1; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Pycnometric method	11
POMD	4 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	UV-spectroscopy	1
POMD	4 1	Mass density, kg/m3 ; Liquid	Amount concentration (molarity), mol/dm3 - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Pycnometric method	1
POMD	3 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	UV-spectroscopy	1
POMD	3 1	Mass density, kg/m3 ; Liquid	Amount concentration (molarity), mol/dm3 - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Pycnometric method	1
POMD	2 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	UV-spectroscopy	1
POMD	2 1	Mass density, kg/m3 ; Liquid	Amount concentration (molarity), mol/dm3 - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Pycnometric method	1
POMD	5 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	UV-spectroscopy	1
POMD	5 1	Mass density, kg/m3 ; Liquid	Amount concentration (molarity), mol/dm3 - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Pycnometric method	1
POMD	6 1	Amount concentration (molarity), mol/dm3 - 1 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal - 1	UV-spectroscopy	1
POMD	6 1	Mass density, kg/m3 ; Liquid	Amount concentration (molarity), mol/dm3 - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Pycnometric method	1

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Lamotrigine Solubility in Some Nonaqueous Solvent Mixtures at 298.2 K

Farjami, A.[Afsaneh], Jouyban, A.[Abolghasem]

ABSTRACT