ABSTRACT

Densities, , and speeds of sound, u, of flucloxacillin sodium in water and aqueous NaCl solutions were measured at T = (298.15, 303.15, 308.15, 313.15, 318.15, and 323.15) K and atmospheric pressure using a high precision vibrating U-tube digital density and sound velocity analyzer (DSA 5000, Anton Paar, Austria). From the experimental data, apparent molar volume, v, apparent molar adiabatic compressibility, k, limiting apparent molar volume, v0, limiting apparent molar adiabatic compressibility, k0, and critical micelle concentration of flucloxacillin sodium were calculated. The limiting apparent molar volumes, v0, were used to calculate Hepler s constant. The results were interpreted in terms of solute solvent and solute solute interactions and structure making/breaking ability of the solute in the aqueous environment.

Compounds

#	Formula	Name
1	C19H16ClFN3NaO5S	sodium (2S,5R,6R)-6-(3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
2	ClNa	sodium chloride
3	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	6
POMD	3	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	6
POMD	1 2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Amount concentration (molarity), mol/dm3 - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	534
POMD	1 2 3	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Solvent: Amount concentration (molarity), mol/dm3 - 2; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	534
POMD	1 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	54
POMD	1 3	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	54
POMD	2 3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Amount concentration (molarity), mol/dm3 - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	36
POMD	2 3	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Amount concentration (molarity), mol/dm3 - 2; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	36

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Apparent Molar Volume, Adiabatic Compressibility, and Critical Micelle Concentration of Flucloxacillin Sodium in Aqueous NaCl Solutions at Different Temperatures

Khatun, M. R., Islam, M. M., Rima, F. R.[Farhana Rahman], Islam, M. N.

ABSTRACT