Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

ABSTRACT

At the temperature range (273.15 to 308.15) K, the solubility of amorphous clopidogrel hydrogen sulfate (CHS) in pure 1-butanol, 2-butanol, 2-propanol, methyl acetate, ethyl acetate, acetone, and methyl tert-butyl ether (MTBE) were experimentally measured. The order of solubility of amorphous CHS is 1-butanol greater than acetone greater than 2-propanol greater than 2-butanol greater than methyl acetate greater than ethyl acetate greater than MTBE, which is in good agreement with the orders of CHS crystalline forms in the literature. However, the solubility of the amorphous ones is dozens of times higher than that of crystals, respectively. In addition, the modified Apelblat equation was used to correlate the temperature with the mole fraction solubility. Finally, the thermodynamic parameters were calculated by the fitting parameters of the modified Van t Hoff equation.