ABSTRACT

A modified synthetic method with a high definition visual camera technique for measuring the solubility of solutes in solvents or mixed solvents was proposed. To verify the reliability of the experimental apparatus, the solubility of NH4Cl in water was determined at different temperatures. The relative standard errors were less than 1%, compared to the literature data. The solubilities of betulonic acid in six organic solvents from (278.15 to 313.15) K were measured and correlated with the Apelblat equation and universal quasichemical equation, respectively. The modified method was quite concise and user-friendly, and made the process of dissolution to become visualized and automatic.

Compounds

#	Formula	Name
1	CH4O	methanol
2	C2H6O	ethanol
3	C3H8O	propan-1-ol
4	C3H8O	propan-2-ol
5	C3H8O2	2-methoxyethan-1-ol
6	C5H12O2	2-propoxyethanol
7	C30H46O3	3-oxolup-20(29)-en-28-oic acid
8	ClH4N	ammonium chloride (NH4Cl)
9	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	7	Normal melting temperature, K ; Crystal			Crystal Liquid Air at 1 atmosphere	DTA	1
POMD	7	Molar enthalpy of transition or fusion, kJ/mol ; Crystal			Crystal Liquid Air at 1 atmosphere	DSC	1
POMD	1 7	Mole fraction - 7 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 7	visual	9
POMD	2 7	Mole fraction - 7 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 7	visual	9
POMD	3 7	Mole fraction - 7 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 7	visual	9
POMD	4 7	Mole fraction - 7 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 7	visual	9
POMD	5 7	Mole fraction - 7 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 7	visual	9
POMD	6 7	Mole fraction - 7 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 7	visual	9
POMD	9 8	Mass ratio of solute to solvent - 8 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 8	visual	3

Thermodynamics Research Center / ThermoML | Journal of Chemical and Engineering Data

Modified Method for Measuring the Solubility of Pharmaceutical Compounds in Organic Solvents by Visual Camera

Tang, N.[Ning], Shi, W.[Wei], Yan, W.[Weidong]

ABSTRACT