Although the amorphous state has been successfully employed for developing many poorly soluble drugs, a sufficient understanding of the crystallization behavior of pharmaceutical glass has not yet been achieved. This paper describes the importance of a comprehension of the nucleation process for controlling the crystallization of pharmaceutical glasses using celecoxib (CEL) as a model compound. The optimum temperature for nucleation of CEL glass was found to be ca. -50 deg C by exploratory isothermal annealing at various temperatures. After annealing, cold crystallization was observed in a reproducible manner only when the nuclei were created at sufficiently low temperatures. This observation indicates the importance of a knowledge of the optimum nucleation temperature, which may be very low temperature, when amorphous solid dispersions are stored.
Compounds
#
Formula
Name
1
C17H14F3N3O2S
celebrex
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.