Thermodynamics Research Center / ThermoML | Thermochimica Acta

Differential scanning calorimetry and thermally stimulated depolarization currents study on the molecular dynamics in amorphous fenofibrate

Diogo, H. P.[Herminio P.], Viciosa, M. T.[Maria Teresa], Ramos, J. J. M.[Joaquim J. Moura]
Thermochim. Acta 2016, 623, 29-35
ABSTRACT
The slow molecular mobility of the active pharmaceutical drug fenofibrate is studied by differential scanning calorimetry (DSC) and thermally stimulated depolarization currents (TSDC). The general kinetic features of the secondary relaxations and of the main relaxation, in particular their distribution of relaxation times, were determined by TSDC. Different experimental procedures were used to determine the fragility index by DSC and the obtained results were discussed. The TSDC fragility is in very good agreement with the value obtained by dielectric relaxation spectroscopy (DRS), and all the DSC, TSDC and DRS values indicate that fenofibrate is a very fragile liquid. Given that this means a strong aging sensitivity, we profited from this property to evaluate the influence of physical aging on the fragility values determined by TSDC. From the results of experiments designed to achieve this goal we can conclude that this influence can be considered as negligible.
Compounds
# Formula Name
1 C20H21ClO4 fenofibrate
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal 1
  • Crystal 1
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal 2
  • Crystal 2
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 1
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 1
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal 1
  • Crystal 1
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 1
  • Triple point temperature, K ; Glass
  • Glass
  • Liquid
  • Air at 1 atmosphere
  • Thermally stimulated depolarization currents method
  • 1