ABSTRACT

Densities (r) and speeds of sound (u) of betaine hydrochloride (B.HCl) drug (0.01 0.06) mol kg 1 in (0.10, 0.20 and 0.30) mol kg 1aqueous NaCl and KCl solutions have been reported as a function of temperature at T = (293.15 313.15) K and at atmospheric pressure. Using experimental data the apparent molar volume (V2,f), partial molar volume (V2 1), transfer partial molar volume (DtV2 1), apparent molar isentropic compressibility (Ks,2,f), partial molar isentropic compressibility (Ks,2 1), transfer partial molar isentropic compressibility (DtKs,2 1), partial molar expansion (E2 1) and Hepler s constant (d2V2 1/dT2)P were calculated. Further, all these parameters are employed to understand the temperature and cosolute effects on B.HCl drug solvent interactions. Cosphere overlap model is used to analyze the hydrophilic/ ionic-ionic interactions in (B.HCl drug + NaCl/KCl + H2O) ternary mixture. The sign of Hepler s constant have been used to interpret the structure making or braking tendency of B.HCl drug in aqueous NaCl and KCl solutions at probed compositions and temperatures

Compounds

#	Formula	Name
1	C5H12ClNO2	betaine hydrochloride
2	ClNa	sodium chloride
3	ClK	potassium chloride
4	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	105
POMD	1 2 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	105
POMD	1 3 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	100
POMD	1 3 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	100
POMD	2 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	2 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15
POMD	3 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	3 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Volumetric properties of betaine hydrochloride drug in aqueous NaCl and KCl solutions at different temperatures

Ryshetti, S.[Suresh], Chennuri, B. K.[Bharath Kumar], Noothi, R.[Raghuram], Tangeda, S. J.[Savitha Jyostna], Gardas, R. L.[Ramesh L.]

ABSTRACT