Solubility and dissolution thermodynamics of N-(4-chlorophenyl)-2-(pyridin-4-ylcarbonyl)hydrazinecarbothioamide in PG + water cosolvent mixtures at (298.15 to 338.15) K
Bhat, M. A.[Mashooq A.], Haq, N.[Nazrul], Shakeel, F.[Faiyaz]
The objective of present investigation was to measure the solubility and dissolution thermodynamics of N-(4-chlorophenyl)-2-(pyridin-4-ylcarbonyl)hydrazinecarbothioamide [isoniazid (INH) analog] in vari- ous propylene glycol (PG) + water co-solvent mixtures from (298.15 to 338.15) K. The experimental solubilities of INH analog were correlated with Apelblat and Yalkowsky models. The root mean square deviations were found to be (1.13-3.98)% and (1.45-5.73)% for Apelblat equation and Yalkowsky model, respectively. Good correlation was observed between experimental and calculated solubilities of INH analog with correlation coefficients in the range of 0.995 0.999. The mole fraction solubility of INH analog was found to be highest and lowest in pure PG (7.38.10-3 at 298.15 K) and pure water (5.17.10-7 at 298.15 K), respectively. The results of dissolution thermodynamics indicated endothermic and non-spontaneous dissolution of INH analog.
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.