ABSTRACT

We have studied thermodynamics of interaction between some amino acids and ethylene glycol (Eg) which is a stabilizing agent for proteins in water using calorimetric and solubility data. Enthalpic, entropic and free energy parameters in highly diluted aqueous solutions have been computed at 298 and 313 K using the virial expansion technique and compared with available literature values. The results obtained are discussed in terms of solute-solute interactions and their relation to stability of macromolecules.

Compounds

#	Formula	Name
1	C2H5NO2	2-aminoacetic acid
2	C2H6O2	1,2-ethanediol
3	H2O	water
4	C6H9N3O2	L-histidine
5	C9H11NO2	L-phenylalanine
6	C6H6	benzene

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 2; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 1; Liquid	Liquid	ISOPERIBOL	20
POMD	4 2 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 2; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 4; Liquid	Liquid	ISOPERIBOL	21
POMD	5 2 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 2; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 5; Liquid	Liquid	ISOPERIBOL	17
POMD	6 2 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 2; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 6; Liquid	Liquid	ISOPERIBOL	27
POMD	1 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 1; Liquid	Liquid	ISOPERIBOL	2
POMD	4 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 4; Liquid	Liquid	ISOPERIBOL	2
POMD	5 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 5; Liquid	Liquid	ISOPERIBOL	2
POMD	6 3	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 6; Liquid	Liquid	ISOPERIBOL	2

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Thermodynamics of the amino acid -ethylene glycol pair interaction

Kustov, A. V.[Andrey V.], Antonova, O. A.[Olga A.], Smirnova, N. L.[Nataliya L.]

ABSTRACT