Thermodynamics Research Center / ThermoML | Thermochimica Acta

Thermo-physical examination: Synthesized 2-furano-4(3H)-quinazolinone and open quinazolinone (diamide) anticancer analogs with sodium dodecyl sulfate

Bhardwaj, V.[Varun], Sharma, P.[Poonam], Noolvi, M. N. N. ].[Malleshappa N.], Patel, H. M. M. ].[Harun M.], Chauhan, S., Chauhan, M. S., Sharma, K.[Kundan]
Thermochim. Acta 2013, 573, 65-72
ABSTRACT
In this study, the solution and self aggregation properties of sodium dodecyl sulfate (SDS) in presence of synthesized small molecules i.e. 3-(2-chloro benzylideneamine))-2-(furan-2-yl) quinazoline-4(3H) one (Q1) and N-(2-(p-tolyl carbamoyl) phenyl) furan-2-carboxamide (Q2) has been determined. The two compounds were earlier screened for anticancer activity from NCI, USA. In order to investigate the physico-chemical properties, simple and controlled methods were employed to obtain critical micellar concentration (CMC) values and thermo-acoustic parameters via conductance, compressibility coefficient, apparent molar voluem and apparent adiabatic compressibility of SDS in the presence of Q1/Q2 at different temperatures (25, 30, and 35degC). In addition, the effect of the addition of Q1/Q2 in SDS solution and to gain information regarding interaction between the molecules, FTIR and 1H NMR spectroscopic analysis was also carried out. The presence of different substitutions on the molecules affecting SDS behavior has also been discussed.
Compounds
# Formula Name
1 C19H12ClN3O2 3-[[(2-chlorophenyl)methylene]amino]-2-(2-furanyl)-4(3H)-quinazolinone
2 C18H15N3O5S N-[2-[[[4-(aminosulfonyl)phenyl]amino]carbonyl]phenyl]-2-furancarboxamide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • Unspecified
  • 1
  • POMD
  • 2
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • Unspecified
  • 1