ABSTRACT

The interactions of Alanyl-L-alanine (Ala-Ala), Alanyl-L-valine (Ala-Val), Alanyl-L-leucine (Ala-Leu) with drug ampicillin (AMP) as a function of temperature have been investigated by combination of volumetric and acoustic methods. Densities and speeds of sound of dipeptides of alanine in aqueous solutions of ampicillin have been measured at T = (305.15, 310.15 and 315.15) K and atmospheric pressure. The apparent molar volume (V.), the partial molar volume (V.0) and standard partial molar volumes of transfer ( centsV..) for glycine and its dipeptides from water to aqueous ampicillin solutions have been calculated from density data. Partial molar adiabatic compressibility (K.) and partial molar adiabatic compressibility of transfer ( centsK.0) have been calculated from speed of sound data. The pair and triplet interaction coefficient have been calculated from both the properties. The results have been explained based on competing patterns of interactions of co-solvents and the solute.

Compounds

#	Formula	Name
1	C16H19N3O4S	6-[D-(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
2	C6H12N2O3	L-alanyl-L-alanine
3	C8H16N2O3	L-alanyl-L-valine
4	C9H18N2O3	L-alanyl-L-leucine
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	3
POMD	5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube	3
POMD	1 2 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	132
POMD	1 2 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	132
POMD	1 3 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid Solvent: Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	132
POMD	1 3 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid Solvent: Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	132
POMD	1 4 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid Solvent: Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	132
POMD	1 4 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid Solvent: Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	132
POMD	2 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	2 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	30
POMD	1 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	9
POMD	1 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	9
POMD	3 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	3 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	30
POMD	4 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	30
POMD	4 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	vibrating tube:WF =	30

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Solvation behaviour of dipeptides of alanine in aqueous solutions of antibacterial drug ampicillin at different temperatures

Kumar, H.[Harsh], Singla, M.[Meenu], Jindal, R.[Rajeev]

ABSTRACT