ABSTRACT

We have studied thermodynamics of the l-phenylalanine (Phe) pair interaction with denaturing agents urea (U) and dimethylformamide (DMF) at 288 318 K. Our study does indicate that enthalpies andentropies of the Phe U interaction reveal the anomalous temperature dependence which does not occurfor DMF solutions. The anomalous Phe behavior in U solutions appears to be closely related to peculiaritiesof U hydration. One more result is in the fact that for hydrophobic solutes such as l-phenylalanine andsubstituted amides it is not justified to use the results obtained at 298 K for predicting the solute behaviorat physiological temperatures.

Compounds

#	Formula	Name
1	C3H7NO	dimethylformamide
2	H2O	water
3	C9H11NO2	L-phenylalanine

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2	Molar enthalpy of solution, kJ/mol ; Liquid	Mole fraction - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Calvet calorimetry	1
POMD	3 1 2	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid Solvent: Mole fraction - 1; Liquid	Molality, mol/kg - 3; Liquid Pressure, kPa; Liquid	Liquid	Calvet calorimetry	56
POMD	3 2	Molar enthalpy of solution, kJ/mol ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid Molality, mol/kg - 3; Liquid	Liquid	Calvet calorimetry	6

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Amino acid behavior in aqueous amide solutions: Temperature dependence ofthe l-phenylalanine N,N-dimethylformamide interaction

Kustov, A. V.[Andrey V.]

ABSTRACT