ABSTRACT

The interactions of glycine (gly), glycine-glycine (gly-gly), glycine-leucine (gly-leu) with drug ampicillin as a function of temperature have been investigated by combination of volumetric and acoustic methods. Densities and speeds of sound of glycine and its dipeptides in aqueous solutions of ampicillin have been measured at T = (305.15, 310.15 and 315.15) K and atmospheric pressure. The apparent molar volume (V.), the partial molar volume (V. 0) and standard partial molar volumes of transfer ( centsV..) for glycine and its dipeptides from water to aqueous ampicillin solutions have been calculated from density data. Partial molar adiabatic compressibility (K.) and partial molar adiabatic compressibility of transfer ( centsK. 0) have been calculated from speed of sound data. The pair and triplet interaction coefficient have been calculated from both the properties. The absorption spectra have also been recorded for present mixtures with the help of UV-visible spectrophotometer. The results have been explained on the basis of competing patterns of interactions of co-solvents and the solute.

Compounds

#	Formula	Name
1	C4H8N2O3	glycylglycine
2	C8H16N2O3	glycyl-L-leucine
3	C2H5NO2	2-aminoacetic acid
4	C16H19N3O4S	6-[D-(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	3
POMD	5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	3
POMD	1 5	Speed of sound, m/s ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	18
POMD	1 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	18
POMD	3 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	18
POMD	3 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	18
POMD	2 5	Speed of sound, m/s ; Liquid	Molality, mol/kg - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	15
POMD	2 5	Mass density, kg/m3 ; Liquid	Molality, mol/kg - 2; Liquid Temperature, K; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	15
POMD	4 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	13
POMD	4 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	12
POMD	3 4 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	60
POMD	3 4 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	60
POMD	4 1 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	60
POMD	4 1 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	60
POMD	4 2 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Sing-around technique in a fixed-path interferometer	60
POMD	4 2 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid Solvent: Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	60

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Interaction of antibacterial drug ampicillin with glycine and its dipeptides analyzed by volumetric and acoustic methods at different temperatures

Kumar, H.[Harsh], Kaur, K.[Kirtanjot]

ABSTRACT