Solubility of mitomycin C drug in ethanol-water solutions was measured at different temperatures (0 to 50oC) using high performance liquid chromatography. It was observed that the solubility of mitomycin C increases with temperature up to certain concentration of ethanol-water, after that it reduces due to several solute-solvent actions. The process is quite useful for developing nanocrystals of mitomycin C by changing the concentration of co-solvent mixture. From the observations of the present study, it may be suggested that for cardiovascular, ophthamalic and cancer applications of mitomycin C one can use ethanol-water co-solvent mixture for deriving nanocrystals. A modified Apelblat equation was used to correlate the experimental data.
Compounds
#
Formula
Name
1
C15H18N4O5
ametycine
2
C2H6O
ethanol
3
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.