ABSTRACT

Dissolution enthalpies of DL- ?-alanyl-DL-norleucine in binary mixtures containing water + (EtOH, 1-PrOH and 2-PrOH at 0 0.4 mole fraction) at 298.15 K and atmospheric pressure have been determined as a function of the composition using an isothermic calorimeter. The results obtained have been used to calculate standard enthalpies of a solution and transfer of DL- ?-alanyl-DLnorleucine from water into the mixtures as well as enthalpy coefficients of pairwise interaction (hxy) of the solute with alcohols in aqueous media. The values are positive for all mixtures over the whole composition range. The influence of the co-solvent structure and of the content of mixtures and of a side-chain of peptide on the change of (hxy) is discussed.

Compounds

#	Formula	Name
1	C9H18N2O3	alanylnorleucine
2	C2H6O	ethanol
3	C3H8O	propan-1-ol
4	C3H8O	propan-2-ol
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	2	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Standard Abbe refractometry	1
POMD	3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	3	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Standard Abbe refractometry	1
POMD	4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Vibrating tube method	1
POMD	4	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Standard Abbe refractometry	1
POMD	1 2 5	Molar enthalpy of solution, kJ/mol ; Liquid	Solvent: Molality, mol/kg - 2; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Isothermal displacement	12
POMD	1 3 5	Molar enthalpy of solution, kJ/mol ; Liquid	Solvent: Molality, mol/kg - 3; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Isothermal displacement	12
POMD	1 4 5	Molar enthalpy of solution, kJ/mol ; Liquid	Solvent: Molality, mol/kg - 4; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Isothermal displacement	12
POMD	1 5	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid		Liquid	Isothermal displacement	1

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Influence of the composition of aqueous-alcohol solvents on the thermodynamic characteristics of DL-a-alanyl-DL-norleucine dissolution at 298.15K

Smirnov, V. I.[Valeriy I.], Badelin, V. G.[Valentin G.]

ABSTRACT