The solubilities of dexibuprofen in five solvents including methanol, n-butyl alcohol, isobutyl alcohol, n-amyl alcohol, n-octyl alcohol were measured in the temperature range (263.15 and 293.15) K under atmospheric pressure. The results indicate that the solubilities of dexibuprofen in the selected solvents increase with temperature. The experimental data were correlated by the modified Apelblat model which fit well with the experimental data. The dissolution enthalpy and entropy of both racibuprofen and dexibuprofen were predicted. Moreover, the solubility data of both of them were correlated using two local composition models: NRTL 1 and UNIQUAC. It is indicated that for dexibuprofen, the NRTL 1 model can provide more accurate estimations of the solubility in the solvents of methanol, ethanol and n-propyl alcohol, while both NRTL 1 and UNIQUAC models can provide good estimations of the solubility in other solvents. For the rac-ibuprofen, the UNIQUAC model performs better to estimate the solubility in all the solvents.
Compounds
#
Formula
Name
1
C13H18O2
(S)-2-(4-isobutylphenyl)propanoic acid
2
CH4O
methanol
3
C4H10O
butan-1-ol
4
C4H10O
2-methyl-1-propanol
5
C5H12O
pentan-1-ol
6
C8H18O
octan-1-ol
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.