ABSTRACT

Thermal analysis carried out on the two binary systems between lidocaine and D-camphor, on the one hand, and DL-camphor, on the other hand, has shown that both systems form eutectic mixtures which are liquid at room temperature. Since these three substances present anesthetic properties, the mixtures elaborated from them are suitable for topical anesthesia. The similar behavior of D- and DL-camphor, regarding melting and crystallographic properties, implies similar binary temperature-composition phase diagrams when they are mixed with lidocaine.

Compounds

#	Formula	Name
1	C14H22N2O	2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
2	C10H16O	1,7,7-trimethylbicyclo[2.2.1]-2-heptanone
3	C10H16O	d-camphor

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2	Triple point temperature, K ; Crystal 2			Crystal 2 Crystal 1 Air at 1 atmosphere	DTA	1
POMD	3	Triple point temperature, K ; Crystal 2			Crystal 2 Crystal 1 Air at 1 atmosphere	DTA	1
POMD	1 3	Eutectic composition: mole fraction - 1 ; Crystal - 1			Crystal - 1 Crystal - 3 Liquid Air at 1 atmosphere	Derived from phase diagram analysis	1
POMD	1 3	Molar enthalpy, kJ/mol ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal	Small sample (50 mg) DSC	1
POMD	1 3	Solid-liquid equilibrium temperature, K ; Liquid	Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 3	DTA	10
POMD	1 3	Solid-liquid equilibrium temperature, K ; Liquid	Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	DTA	7
POMD	1 3	Eutectic temperature, K ; Liquid	Pressure, kPa; Liquid		Liquid Crystal - 1 Crystal - 3	DTA	1
POMD	2 1	Eutectic composition: mole fraction - 1 ; Crystal - 2			Crystal - 2 Crystal - 1 Liquid Air at 1 atmosphere	Derived from phase diagram analysis	1
POMD	2 1	Molar enthalpy, kJ/mol ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid		Liquid Crystal	Small sample (50 mg) DSC	1
POMD	2 1	Solid-liquid equilibrium temperature, K ; Liquid	Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 2	DTA	13
POMD	2 1	Solid-liquid equilibrium temperature, K ; Liquid	Mole fraction - 1; Liquid	Pressure, kPa; Liquid	Liquid Crystal - 1	DTA	8
POMD	2 1	Eutectic temperature, K ; Liquid	Pressure, kPa; Liquid		Liquid Crystal - 2 Crystal - 1	DTA	1

Thermodynamics Research Center / ThermoML | Thermochimica Acta

INCIDENCE OF CHIRALITY ON THE PROPERTIES OF MIXTURES CONTAINING AN AMIDE TYPE ANESTHETIC COMPOUND

Corvis, Y.[Yohann], Espeau, P.[Philippe]

ABSTRACT