Thermodynamics Research Center / ThermoML | Thermochimica Acta

Thermodynamic studies of mixtures for topical anesthesia: Lidocaine-salol binary phase diagram

Lazerges, M.[Mathieu], Rietveld, I. B.[Ivo B.], Corvis, Y.[Yohann], Ceolin, R.[Rene], Espeau, P.[Philippe]
Thermochim. Acta 2010, 497, 1-2, 124-128
ABSTRACT
The lidocaine-salol binary system has been investigated by differential scanning calorimetry, direct visual observations, and X-ray powder diffraction, resulting in a temperature-composition phase diagram with a eutectic equilibrium. The eutectic mixture, found at 0.423+-0.007 lidocaine molefraction, melts at 18.2+-0.5 deg C with an enthalpy of 17.3+-0.5 kJ.mol-1. This indicates that the liquid phase around the eutectic composition is stable at room temperature. Moreover, the undercooled liquid mixture does not easily crystallize. The present binary mixture exhibits eutectic behavior similar to the prilocaine-lidocaine mixture in the widely used EMLA(R) topical anesthetic preparation.
Compounds
# Formula Name
1 C13H10O3 phenyl salicylate
2 C14H22N2O 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 2
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DSC
  • 1
  • POMD
  • 2
  • Normal melting temperature, K ; Crystal
  • Crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 1
  • 2
  • Eutectic temperature, K ; Crystal - 1
  • Crystal - 1
  • Crystal - 2
  • Liquid
  • Air at 1 atmosphere
  • DTA
  • 1
  • POMD
  • 1
  • 2
  • Eutectic composition: mole fraction - 2 ; Crystal - 1
  • Crystal - 1
  • Crystal - 2
  • Liquid
  • Air at 1 atmosphere
  • Derived from phase diagram analysis
  • 1
  • POMD
  • 1
  • 2
  • Solid-liquid equilibrium temperature, K ; Liquid
  • Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 1
  • DTA
  • 18
  • POMD
  • 1
  • 2
  • Solid-liquid equilibrium temperature, K ; Liquid
  • Mole fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Crystal - 2
  • DTA
  • 14