ABSTRACT

The enthalpies of solution of 2,4,6,8-tetramethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione or tetramethyl-bis-urea (the drug Mebicarum) in formamide, N-methylformamide, N,N-dimethylformamide, N,Ndimethylacetamide, N,N,N',N'-tetramethylurea, and acetone were measured at 298.15 K. Standard enthalpies of solution and transfer from one solvent to another were computed. The enthalpies of solution of the solute were found to be endothermic and weak-depending on the nature of methylation in an amide molecule. It was concluded that the solvent proton-donor ability and existing steric hindrances for H-bonding and other interparticle interactions play the key role in solvation of tetramethyl-bis-urea.

Compounds

#	Formula	Name
1	C8H14N4O2	1,3,4,6-tetramethylglycoluril
2	CH3NO	formamide
3	C2H5NO	N-methylformamide
4	C3H7NO	dimethylformamide
5	C4H9NO	N,N-dimethylethanamide
6	C5H12N2O	tetramethylurea
7	C3H6O	acetone

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Phase	Method	#Points
POMD	1	Normal melting temperature, K ; Crystal		Crystal Liquid Air at 1 atmosphere	UNKNOWN	1
POMD	2	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	1
POMD	2	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	1
POMD	3	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	1
POMD	3	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	1
POMD	4	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	1
POMD	4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	1
POMD	5	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	1
POMD	5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	1
POMD	6	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	1
POMD	6	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	1
POMD	7	Refractive index (Na D-line) ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Standard Abbe refractometry	1
POMD	7	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	Vibrating tube method	1
POMD	2 1	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	ISOPERIBOL	1
POMD	3 1	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	ISOPERIBOL	1
POMD	4 1	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	ISOPERIBOL	1
POMD	5 1	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	ISOPERIBOL	1
POMD	6 1	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	ISOPERIBOL	1
POMD	7 1	Molar enthalpy of solution, kJ/mol ; Liquid	Molality, mol/kg - 1; Liquid Temperature, K; Liquid Pressure, kPa; Liquid	Liquid	ISOPERIBOL	1

Thermodynamics Research Center / ThermoML | Thermochimica Acta

Enthalpies of solution of tetramethyl-bis-urea (Mebicarum) in amides and acetone at 298.15 K

Ivanov, E. V.[Evgeniy V.], Abrosimov, V. K.[Vladimir K.], Smirnov, V. I.[Valeriy I.]

ABSTRACT