Thermodynamics Research Center / ThermoML | Thermochimica Acta

Pressurization effects on the polymorphic forms of famotidine

Nemet, Z.[Zoltan], Hegedus, B.[Bela], Szantay, C., Jr.[Csaba, Jr.], Sztatisz, J., Pokol, G.[Gyorgy]
Thermochim. Acta 2005, 430, 1-2, 35-41
ABSTRACT
The effects of high static pressure on the polymorphic modifications A and B of famotidine were examined by differential scanning calorimetry, infrared and Raman spectroscopy, and X-ray powder diffractometry. The obtained effects appeared to differ significantly depending on whether they were monitored by DSC or any of the other above techniques. In particular, DSC measurements tend to deceptively amplify a tendency of the pure modification B to turn into the more stable form A under pressurization, while the spectroscopic methods and XRPD exhibit no essential change in the crystal structure of the metastable form B. The apparent morphological transformation in the pressed samples stems from the nature of the DSC method itself.
Compounds
# Formula Name
1 C8H15N7O2S3 famotidine
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • Molar enthalpy of transition or fusion, kJ/mol ; Metastable crystal
  • Metastable crystal
  • Liquid
  • Air at 1 atmosphere
  • DSC:FP
  • 1
  • POMD
  • 1
  • Molar enthalpy of transition or fusion, kJ/mol ; Crystal 1
  • Crystal 1
  • Liquid
  • Air at 1 atmosphere
  • DSC:FP
  • 1
  • POMD
  • 1
  • Normal melting temperature, K ; Metastable crystal
  • Metastable crystal
  • Liquid
  • Air at 1 atmosphere
  • DTA:corrimp:FP
  • 1
  • POMD
  • 1
  • Normal melting temperature, K ; Crystal 1
  • Crystal 1
  • Liquid
  • Air at 1 atmosphere
  • DTA:corrimp:FP
  • 1