Thermodynamics Research Center, ThermoML : Journal of Chemical Thermodynamics

Volumetric, acoustic and viscometric investigation of ceftriaxone disodium in aqueous solutions of 1-propanol and 2-propanol

Mehrdad, Abbas, Hajikarimi, Mohsen
J. Chem. Thermodyn. 2019, 139, 105880
ABSTRACT
The extraction and purification of ceftriaxone disodium from aqueous solution carried out with organic solvents. Therefore volumetric, acoustic and viscometric properties of ceftriaxone disodium in aqueous solutions of 1-propanol and 2-propanol were investigated at T/K = (288.15-308.15). The apparent molar volumes and isentropic compressibility values in dilute region were fitted to Redlich-Mayer equation. The infinite dilution apparent molar transfer volumes, deltatrVphio, were often negative and increased with increasing the concentration of 1-propanol and 2-propanol. This behaviour reveals that there are strong ionic-polar interactions between ions of CFNa and 1-propanol or 2-propanol with respect to water; because the polarizability of 1-propanol and 2-propanol is greater than those of water. The apparent molar isentropic compressibility at infinite dilution, kappaphio, of CFNa in the aqueous solutions of 1-propanol and 2-propanol are higher than those of pure water. Therefore the CFNa was dehydrated with addition of 1-propanol or 2-propanol. To obtain viscosity B and D coefficients, the viscosities data were fitted to the Jones-Dole equation. The viscosity B-coefficient of CFNa in the aqueous solutions of 1-propanol and 2-propanol was lower than those of CFNa pure water. Therefore it can be concluded that CFNa solvated in water rather than the aqueous solutions of 1-propanol and 2-propanol.
Compounds
# Formula Name
1 C18H16N8Na2O7S3 disodium ceftriaxone
2 C3H8O propan-1-ol
3 C3H8O propan-2-ol
4 H2O water
Datasets
The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type Compound-# Property Variable Constraint Phase Method #Points
  • POMD
  • 1
  • 4
  • 2
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 2; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 144
  • POMD
  • 1
  • 4
  • 2
  • Viscosity, Pa*s ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 2; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Falling or rolling sphere viscometry
  • 144
  • POMD
  • 1
  • 4
  • 2
  • Speed of sound, m/s ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 2; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Frequency, MHz; Liquid
  • Liquid
  • Single path-length method
  • 144
  • POMD
  • 1
  • 4
  • 3
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 3; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 84
  • POMD
  • 1
  • 4
  • 3
  • Speed of sound, m/s ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 3; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Frequency, MHz; Liquid
  • Liquid
  • Single path-length method
  • 84
  • POMD
  • 1
  • 4
  • 3
  • Viscosity, Pa*s ; Liquid
  • Temperature, K; Liquid
  • Solvent: Mass fraction - 3; Liquid
  • Molality, mol/kg - 1; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Falling or rolling sphere viscometry
  • 84
  • POMD
  • 4
  • 2
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Mass fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 16
  • POMD
  • 4
  • 2
  • Viscosity, Pa*s ; Liquid
  • Temperature, K; Liquid
  • Mass fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Falling or rolling sphere viscometry
  • 16
  • POMD
  • 4
  • 2
  • Speed of sound, m/s ; Liquid
  • Temperature, K; Liquid
  • Mass fraction - 2; Liquid
  • Pressure, kPa; Liquid
  • Frequency, MHz; Liquid
  • Liquid
  • Single path-length method
  • 16
  • POMD
  • 4
  • 3
  • Mass density, kg/m3 ; Liquid
  • Temperature, K; Liquid
  • Mass fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Vibrating tube method
  • 12
  • POMD
  • 4
  • 3
  • Speed of sound, m/s ; Liquid
  • Temperature, K; Liquid
  • Mass fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Frequency, MHz; Liquid
  • Liquid
  • Single path-length method
  • 12
  • POMD
  • 4
  • 3
  • Viscosity, Pa*s ; Liquid
  • Temperature, K; Liquid
  • Mass fraction - 3; Liquid
  • Pressure, kPa; Liquid
  • Liquid
  • Falling or rolling sphere viscometry
  • 12