ABSTRACT

Ionic liquids have recently been of growing significance in pharmaceutical applications. The effect of some ionic liquids on the thermodynamic and transport characteristics of ceftriaxone sodium (CFNa) drug has been studied in this research. Density, speed of sound, and viscosity of CFNa in 1-butyl-4-methylpyridinium bromide, 1-hexyl-4-methylpyridinium bromide and 1-octyl-4-methylpyridinium bromide aqueous solutions have been measured at T/K = (288.15-308.15). Apparent molar volumes at infinite dilution, transfer apparent molar volume, apparent molar isentropic compressibility at infinite dilution and B and D viscosity coefficients of ceftriaxone sodium have been calculated and discussed with regards to solute-solute and solute-solvent interactions using experimental data. The apparent molar volumes and isentropic compressibility values in dilute region were acquired through fitting density and speed of sound data to Redlich-Mayer equation and the viscosity B and D coefficients values were given by Jones-Dole equation.

Compounds

#	Formula	Name
1	C18H16N8Na2O7S3	disodium ceftriaxone
2	C10H16BrN	1-butyl-4-methylpyridinium bromide
3	C12H20BrN	1-hexyl-4-methylpyridinium bromide
4	C14H24BrN	1-octyl-4-methylpyridinium bromide
5	H2O	water

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	1 2 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	165
POMD	1 2 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	165
POMD	1 2 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 2; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	165
POMD	1 3 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	175
POMD	1 3 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	175
POMD	1 3 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	175
POMD	1 4 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	195
POMD	1 4 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 4; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	195
POMD	1 4 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid Solvent: Mass fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	195
POMD	1 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	45
POMD	1 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	45
POMD	1 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 1; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	45
POMD	2 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Mass fraction - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	20
POMD	2 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Mass fraction - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	20
POMD	2 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Mass fraction - 2; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	20
POMD	3 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	20
POMD	3 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Mass fraction - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	20
POMD	3 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Mass fraction - 3; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	20
POMD	4 5	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Mass fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	20
POMD	4 5	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Mass fraction - 4; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Single path-length method	20
POMD	4 5	Viscosity, Pa*s ; Liquid	Temperature, K; Liquid Mass fraction - 4; Liquid	Pressure, kPa; Liquid	Liquid	Falling or rolling sphere viscometry	20

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Effect of ionic liquids, 1-alkyl-4-methylpyridinium bromides on the volumetric, acoustic and viscometric behaviour of aqueous ceftriaxone sodium solutions

Mehrdad, Abbas, Ghorbanipour, Masoumeh

ABSTRACT