Taylor dispersion is used to measure the binary mutual diffusion coefficient (D) of aqueous solutions of sodium salicylate (NaSal), a non-steroidal anti-inflammatory drug (NSAID). The D.deg. value estimated by extrapolation to zero NaSal concentration is used to calculate the limiting mobility of the Sal- ion for comparison with the value determined previously from conductivity data. Salt effects on NSAID diffusion are studied by measuring the ternary mutual diffusion coefficients (Dik) of aqueous NaSal(C1) + NaCl(C2) solutions, including results for the diffusion of NaSal in physiological saline solutions with C2 = 0.15 mol dm-3. As the NaCl:NaSal ratio increases, NaSal diffusion coefficient D11 changes from the binary diffusion coefficient of aqueous NaSal (a weighted average of the Na+ and Sal- diffusion coefficients) to the tracer diffusion coefficient of the Sal- ion in NaCl solutions. Coupled diffusion in the solutions is analysed by using Nernst-Planck equations to calculate the fluxes of ions migrating in the electric field (diffusion potential) generated by NaSal and NaCl concentration gradients.
Compounds
#
Formula
Name
1
C7H5NaO3
sodium salicylate
2
H2O
water
Datasets
The table above is generated from the ThermoML associated json file (link above).
POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied;
the numbers refer to the table of compounds on the left.