Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

ABSTRACT

Equilibrium solubility of 7-chloro-quinaldine, 7-chloro-quinaldine L-tartrate or 7-chloro-quinaldine p-nitrophthalate in methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol and acetone was measured by static gravimetric method at temperatures from 283.15 K to 323.15 K under p = 101.2 kPa. Within the studied temperature, the solubility of these three compounds in the solvents increased with a rise of temperature. The sequence of solubility of 7-chloro-quinaldine in these solvents (high to low) is acetone greater than isopropanol greater than isobutanol greater than methanol greater than ethanol greater than n-propanol greater than n-butanol. The solubility of 7-chloro-quinaldine tartrate in studied solvents obeys the following order: acetone greater than isopropanol greater than isobutanol greater than ethanol greater than n-propanol greater than n-butanol greater than methanol. While 7-chloro-quinaldine p-nitrophthalate + solvents, it ranked as: isobutanol greater than n-butanol greater than isopropanol greater than acetone greater than n-propanol greater than ethanol greater than methanol. The modified Apelblat equation was used to correlate the solubility values in neat solvents. The maximum values of root-mean-square deviation (RMSD) and relative average deviation (RAD) were 0.83 * 10-4 and 0.93%, respectively. Compared with the results of modified Apelblat equation, the calculated solubility provided good results with the experimental data. The experimental solubility values would be very helpful for application of 7-chloro-quinaldine, 7-chloro-quinaldine L-tartrate or 7-chloro-quinaldine p-nitrophthalate in industry.