ABSTRACT

Thermodynamic properties of l-Alanine and l-Valine in aqueous solutions of drug dolonex, have been investigated by combination of volumetric and acoustic methods at various temperatures (293.15, 298.15, 303.15, 308.15 and 313.15) K and at atmospheric pressure. The experimental data is further used to calculate limiting apparent molar volume, Vophi, limiting apparent molar volume of transfer, Vophi,tr, limiting molar isentropic compression, Kophi,S and limiting apparent molar isentropic compression of transfer, Kophi,S,tr. Furthermore, apparent molar expansivity, Eophi, Hepler constant values, -dEphio-dTP, coefficient of thermal expansion, alpha and hydration number, nH were also calculated. The obtained results were used to interpret solute-solute and solute-solvent interactions in these systems. The volumetric and compressibility data suggests dominance of hydrophilic-hydrophilic interactions in these systems.

Compounds

#	Formula	Name
1	H2O	water
2	C3H7NO2	(S)-2-aminopropanoic acid
3	C5H11NO2	L-valine
4	C15H13N3O4S	4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Datasets

The table above is generated from the ThermoML associated json file (link above). POMD and RXND refer to PureOrMixture and Reaction Datasets. The compound numbers are included in properties, variables, and phases, if specificied; the numbers refer to the table of compounds on the left.
Type	Compound-#	Property	Variable	Constraint	Phase	Method	#Points
POMD	2 1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Solvent: Molality, mol/kg - 4; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	160
POMD	2 1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Solvent: Molality, mol/kg - 4; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	160
POMD	3 1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Solvent: Molality, mol/kg - 4; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	160
POMD	3 1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Solvent: Molality, mol/kg - 4; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	160
POMD	2 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	40
POMD	2 1	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 2; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	40
POMD	1 4	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	20
POMD	1 4	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 4; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	23
POMD	3 1	Mass density, kg/m3 ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid	Liquid	Vibrating tube method	40
POMD	3 1	Speed of sound, m/s ; Liquid	Temperature, K; Liquid Molality, mol/kg - 3; Liquid	Pressure, kPa; Liquid Frequency, MHz; Liquid	Liquid	Linear variable-path acoustic interferometer	40

Thermodynamics Research Center / ThermoML | Journal of Chemical Thermodynamics

Thermo-physical properties of l-Alanine/l-Valine in aqueous solutions of non steroid anti inflammatory drug dolonex at different temperatures: Volumetric and acoustic approach

Sawhney, Neha, Kumar, Mukesh, Sharma, Amit K., Sharma, Meena

ABSTRACT